Maj, Magdalena and Ilhan, Aysegul and Neziri, Dashurie and Gartner, Wolfgang and Berggard, Tord and Attems, Johannes and Base, Wolfgang and Wagner, Ludwig (2011) Age related changes in pancreatic beta cells: A putative extra-cerebral site of Alzheimer’s pathology. World Journal of Diabetes, 2 (4). pp. 49-53. ISSN 1948-9358
Preview |
Text
WJD-2-49.pdf Download (585kB) | Preview |
Abstract
Frequent concomitant manifestation of type 2 diabetes
mellitus (T2DM) and Alzheimer’s disease (AD) has
been recently demonstrated by epidemiological studies.
This might be due to functional similarities between
β-cells and neurons, such as secretion on demand of
highly specific molecules in a tightly controlled fashion.
An additional
similarity represents the age-related
alteration of hyperphosphorylated tau in AD patients.
Similarly, alterations have been identified in β-cells of
T2DM patients. The islet amyloid polypeptide has been
associated with β-cell apoptosis. As a consequence of
increasing age, the accumulation of highly modified proteins
together with decreased regenerative potential
might lead to increasing rates of apoptosis. Moreover, reduction
of β-cell replication capabilities results in reduction
of β-cell mass in mammals, simultaneously with
impaired glucose tolerance. The new challenge is to
learn much more about age-related protein modifications.
This can lead to new treatment strategies for
reducing the incidence of T2DM and AD.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Biljana Kosturanova |
| Date Deposited: | 06 Mar 2013 11:54 |
| Last Modified: | 06 Mar 2013 11:54 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/5746 |
Actions (login required)
 |
View Item |