Periodontal infection as a trigger factor for rheumatoid arthritis

Radojkova-Nikolovska, Vera and Nikolovski, Bruno and Dzipunova, Biljana and Toseska Spasova, Natasa and Dimova, Cena (2024) Periodontal infection as a trigger factor for rheumatoid arthritis. In: International Dental Congress - Dental Naissa'24, 5-7 Apr 2024, University of Nis.

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Abstract

Introduction: The association between periodontal disease and rheumatoid arthritis is the subject of research in many scientific studies. Although the two diseases have different etiologies, it is considered that there is a connection and similarities between many pathophysiological mechanisms that mediate their initiation and maintenance. Even though pathological processes in rheumatoid arthritis and periodontal disease occur in different, distant anatomical parts, in both is observed destruction of bone and the surrounding supportive soft tissues.
Aim: to point out potential mechanisms by which periodontal disease may contribute to the initiation and progression of rheumatoid arthritis, and to clarify current attitudes and the possibility for the existence of a causal relationship between these two common diseases in the human population.
Material and methods: research was done exploring specialized databases PubMed, MEDLINE, EBSCO, Science Direct, and Scopus for the period 2013-2023, by use of MeSH terms: rheumatoid arthritis; periodontal disease ACPA- anticitrullinated protein antibodies; RF- rheumatoid factor; PAD- peptidyl arginine deiminase.
Results: Oral pathogens linked to periodontal disease might trigger the production of autoantigens that cause and sustain inflammatory immune responses in the joints and adjacent tissues in rheumatoid arthritis. Recent scientific studies indicate the important role of Porphyromonas gingivalis, PPAD enzymes, the process of protein citrullination, production of ACPA antibodies, as important factors in the immune response, which will unlock the mechanism of initiation and progression of RA.
Conclusion: In particular, the process of citrullination, a post-translational protein modification, has been highlighted as a process common to both diseases. To what extent periodontal disease can trigger the mechanism of commencement of RA remains an open question, to which future longitudinal clinical trials need to give us the answer.

Keywords: periodontal disease, rheumatoid arthritis, pathogenesis, citrullination, immune responses

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Bruno Nikolovski
Date Deposited:	17 Jun 2024 11:34
Last Modified:	17 Jun 2024 11:35
URI:	https://eprints.ugd.edu.mk/id/eprint/34144

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