Biopharmaceutical characterization of povidone-iodine liposomes

Goracinova, Katerina and Klisarova, Ljiljana and Makraduli, Liljana and Fredro-Kumbaradzi, Emilija and Glavas Dodov, Marija and Mladenovska, Kristina (2000) Biopharmaceutical characterization of povidone-iodine liposomes. Bulletin of the Chemists and Technologists of Macedonia, 19 (2). pp. 133-137. ISSN 0350 - 0136

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Abstract

Different formulations of multilamellar liposomes were prepared from Soya lecithin and poly(l-vinyl-2-
pyrrolidone)iodine complex by a mechanical method, vortexing the phospholipid dispersion in water. Biopharmaceu�tical evaluation and antimicrobial efficacy studies were performed in order to evaluate liposome's potential for use as
a sustained release depo with efficient and prolonged antimicrobial action, compared to PVP-I solution. Varying the
drug/phospholipid ratio during the preparation of the liposomes, different efficacy of PVP-I encapsulation was
achieved. Lower concentrations of PVP-I in the lecithin dispersion for liposome preparation resulted with higher in�corporation efficacy. Dissolution test results point that total drug release (%) from the series within 24 hours was 45.08 ± 1.53, 36.15 ± 1.65, 22.54 ± 1.96, 19.98 ± 1.05 for series A, B, C and D, respectively. The in vitro microbi�ological testing demonstrated good antimicrobial efficiency of PVP-I liposome dispersions against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. Also prolonged antimicrobial action, compared to PVP-I solution was noticed.

Item Type:	Article
Subjects:	Engineering and Technology > Other engineering and technologies Medical and Health Sciences > Other medical sciences Natural sciences > Other natural sciences
Divisions:	Faculty of Medical Science
Depositing User:	Liljana Makraduli
Date Deposited:	29 Mar 2024 09:27
Last Modified:	29 Mar 2024 09:27
URI:	https://eprints.ugd.edu.mk/id/eprint/33895

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