Insulin resistance in patients with depression before and after treatment

Janikevik Ivanovska, Danijela and Manuseva, Nensi and Spasovska Trajanovska, Aneta and Domazetovska, Saska and Stefanovski, Branko (2023) Insulin resistance in patients with depression before and after treatment. In: WorldLab Euromedlab Roma 2023, 21-25 May 2023, Rome, Italy.

Text Janicevic DJ Rome 2023.pdf Download (503kB)

Abstract

A high proportion of patients with depression develop glucose intolerance accompanied by hyperinsulinemia, suggestive of reduced insulin sensitivity (insulin resistance).
The aim of this study was to evaluate insulin sensitivity in patients with depression and its changes during the clinical course and treatment of depression.
Study group consisted of 43 nondiabetic patients with depression (23 males and 20 females aged 40 ± 10 years), body mass index BMI was 23.2 ± 2.8 kg/m2 and an age, sex, and BMI-matched control group (n = 40). We examined oral glucose tolerance test (OGTT) before and after psychopharmacological treatment of depression in duration of 6-8 weeks.
Metabolic indices measuring glucose effectiveness at basal insulin and insulin sensitivity were derived from minimal model analysis. Each patient was treated with antidepressant and diet with 2,000 kcal/day food intake and underwent no exercise therapy.
Insulin sensitivity was significantly lower in patients before treatment versus control subjects (6.0 ± 2.5 mmol/l 13,8 ± 8,6mmol/l P < 0.01). After treatment of depression, a significant increase in insulin sensitivity in treated patient (10.7 ± 7.5 mmol/l P<0.01) followed by clinical improvement with reduction of depressive symptoms was observed without changes in the BMI, fasting blood glucose and basal insulin. This was associated with a decrease in the insulin response during the OGTT.
We can conclude that patients with depression have impaired insulin sensitivity and resultant hyperinsulinemia and that these abnormalities can be resolved after recovery from depression

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Danijela Janikevik
Date Deposited:	20 Feb 2024 06:57
Last Modified:	20 Feb 2024 06:58
URI:	https://eprints.ugd.edu.mk/id/eprint/33704

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