Prostate Specific Antigen in Early Diagnosis of Prostate Carcinoma

Stojanovski, Bobi (2012) Prostate Specific Antigen in Early Diagnosis of Prostate Carcinoma. Other thesis, University Goce Delcev- Stip.

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Abstract

The prostate carcinoma, in highly developed countries takes the high second
place in the frequency of occurring in men who are older than fifty years. In Europe,
as a cause of death of men, the prostate carcinoma takes the second place right
after the lung carcinoma, while in USA it takes the first place. It is considered that
136 men from 1000 who are over fifty years old will have prostate carcinoma by the
age of 80 and about 27 of them will die. In Macedonia there are about 70 new cases
of prostate carcinoma each year, and 90% of them are discovered in the late phase
when complete treatment is impossible.
PSA - Prostate specific antigen is a tumor marker suitable for screening the
prostate carcinoma in population. PSA together with the manual rectal exam (DREdigitorectal
examination) and the transrectal exam with ultrasound (TRUStransrectal
ultrasound), or the transabdominal ehotomografy of the prostate, are
diagnostic procedures for men who are in age over fifty, who don’t have any visible
symptoms for existence of prostate carcinoma. There is a positive correlation
between the PSA in the blood and the tumor stadium.
The purpose of this 12 month study was to determine the PSA value in an
early diagnostics of prostate carcinoma and in the differential diagnostics of the
benign prostate hyperplasia in patients with symptoms that affect the lower part of
the urinary system. In the study, male patients with age over 45 who fulfilled the
criteria were included by random choice. Patients who came for the first exam
because they had symptoms that affect the lower part of the urinary system and had
increased prostate volume during transabdominal ehosonografy exam (> 25ccm)
were included in the study.
The study group consisted of 125 patients: 7 patients < 50 years old, 15
patients between 51-60 years old, 47 patients between 61-70 years old, 49 patients
between 71-80 years old and 7 patients > 81 years old. PSA, DRE and
transabdominal ehosonografy of the prostate were preformed in every one of the
patients.
Based on the results from the PSA serum values and the transabdominal
ehosonografy exam of the prostate, was formed PSA density index in 1 mL prostatic
tissue (PSA density), and was preformed biopsy of the prostate in 46 patients. By
analyzing the results were formed three groups of patients: patients with prostate
carcinoma – 12, patients with benign prostate hyperplasia – 108, patients with
prostatitis – 5.

Item Type:	Thesis (Other)
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Snezana Georgieva Siceva
Date Deposited:	08 Nov 2012 16:21
Last Modified:	14 Nov 2012 12:16
URI:	https://eprints.ugd.edu.mk/id/eprint/660

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