Evrosimovska, Biljana and Dimova, Cena and Kovacevska, Ivona and Panov, Sašo (2012) Concentration of collagenases (MMP-1, -8, -13) in patients with chronically inflamed dental pulp tissue. Contributions, Sec. Biol. Med. Sci., 33 (2). pp. 191-204. ISSN 0351–3254
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Abstract
Matrix metalloproteinases (MMPs) form an enzyme family capable of
degrading almost all extracellular matrix (ECM) and basement membrane (BM) components.
They play an important role in normal tissue remodelling and growth, as well as
in many destructive pathological conditions such as inflammation, tumour growth and
metastasis. The role of MMPs in the breakdown of pulp tissue of teeth with pulpitis has
not yet been directly elucidated.
The purpose of this study was to evaluate the tissue levels of collagenases
(MMP-1, -8, -13) and their distributions in the clinically healthy and chronically inflamed
human dental pulps of 30 patients, aged 15–70 years. Twenty pulps were collected
from subjects diagnosed with chronic pulpitis, and 10 control pulps were obtained from
10 subjects following molar extraction for orthodontic reasons. The levels of collagenases
were determined with an enzyme-linked immunosorbent assay (ELISA). Results
reveal that levels of collagenases were significantly higher in chronically inflamed vs.
clinically normal pulps.
Overall, these results show that MMPs play an important role in ECM destruction
during the inflammatory processes of pulpitis, as well as reflecting the special characteristics
of them. This investigation opens a new opportunity for one contemporarymethod for the diagnosis of pulp inflammations and monitoring of the inflammatory
processes.
Key words: matrix metalloproteinases, collagenases, pulp tissue, pulpitis.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Cena Dimova |
| Date Deposited: | 04 Mar 2013 12:03 |
| Last Modified: | 14 Oct 2014 13:42 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/5702 |
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