Zaidman, Nathan and Bosnakovski, Darko (2012) Advancing with Ceramic Biocomposites for Bone Graft Implants. Recent Patents on Regenerative Medicine, 2 (1).
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Abstract
Bone grafting has come a very long way since a Dutch surgeon used pieces of a dog’s skull to repair a soldier’s
cranium in the 17th Century. Current technology aims to deliver a scaffold that combines the unique osteogenic properties
of ceramic biocomposite materials to make the best mimic of physiologic conditions. To do so, a scaffold must provide: i)
A three-dimensional platform allowing for osteogenic cellular attachment and growth and vascular formation, ii) Structural
integrity while the damaged tissue heals, and iii) Non-toxic integration, degradation or resorption into the host over
an appropriate time. The combination of inorganic, ceramic materials with cells, polymers and growth factors has come
very close to creating a bone graft capable of meeting each of these requirements. Recent patents describe new methods to
forming an ideal osteogenic matrix for both large and small bone repair. Many new technologies have been introduced
that are very potent in their ability to heal small bone wounds and induce new bone formation, such as porous calcium
phosphate pastes and hydroxyapatite cements. However, there is still a lack of quality and proven materials for load bearing
purposes. This is a reminder of how much there still is to improve upon and that we are still a long way from creating
bone products that are identical to the natural product. Despite these shortcomings, ceramic biocomposties represent one
of the most promising materials in the bone graft field and their development and improvement will surely lead to a more
natural bone replacement.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Darko Bosnakovski |
| Date Deposited: | 23 Jan 2013 15:01 |
| Last Modified: | 23 Jan 2013 15:01 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/5044 |
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