Evaluation of in vitro dissolution similarity of bisoprolol film-coated tablets based on Weibull modelling using MATLABTM simulation software

The aim of this study was to compare the in vitro dissolution behaviour of reference (R) and generic-test (T) medicinal
products with non-linear effects model. Mathematical function Weibull, was employed as basis for the non-linear effects
model, coupled with MATLABTM simulation software to describe the release profile of the active substance. Medicinal
products selected for the presented study include immediate-release tablets Concor 10 mg and Bisoprolol 10 mg, which
belongs to BCS class 1 of biopharmaceutics classification system. The result from the study indicated that Weibull
distribution function coupled with computer-based program is more useful for comparison of the dissolution profiles.
This combined approach provides robust and informative results, with accurate estimation on the in vitro performance
for the medicinal products and it’s the most suitable tool for prediction of in vivo behaviour of the medicinal product. In
summary, we have employed Simulink graphical programming to design our system in a simulation environment.