Investigating the relationship between aspirin resistance and clinical severity in acute ischemic stroke patients

Objective: Ischemic stroke outcomes are influenced by initial severity. We aimed to explore the relationship
between aspirin resistance (AR) and stroke severity. Introduction: Stroke severity significantly affects clinical
outcomes. Established tools like NIHSS and MRS assess severity, yet the link between aspirin resistance and these
measures remains uncertain.
Material and Methods: We enrolled 100 acute ischemic stroke patients, assessing severity with NIHSS and MRS
and aspirin resistance using the Innovance PFA 200 system. Statistical analyses employed SPSS 20.0.
Results: Of 100 patients (mean age 61 years, 55% male), 32% showed aspirin resistance. While NIHSS and MRS
correlated with certain clinical parameters, no significant correlation was found between aspirin resistance and
stroke severity.
Discussion: Despite expectations, no significant link emerged between aspirin resistance and stroke severity
measured by NIHSS/MRS. Other factors may outweigh aspirin responsiveness in influencing stroke severity. The
positive correlation between age and aspirin resistance merits further exploration for treatment implications in
older stroke patients. Conclusion: Aspirin resistance was prevalent among acute stroke patients but didn’t impact
stroke severity as measured by NIHSS and MRS. This underscores the need for personalized stroke management
approaches.
Keywords: Aspirin resistance, Stroke, NIHSS Scale, MRS scale,