Primary and permanent teeth pulp stem cells - biological characteristics and therapeutic indications

Stem cell research has opened new avenues in regenerative medicine, offering promising solutions for
tissue restoration and regeneration. Among the various sources of stem cells, dental pulp has emerged as a rich
reservoir of mesenchymal stem cells (MSCs) with remarkable regenerative potential. Pulp stem cells derived from
primary and permanent teeth have attracted attention due to their unique biological properties and clinical
applications. Primary teeth, despite being temporary structures, contain a rich source of MSCs during early
childhood development, while permanent teeth provide a more abundant and accessible reserve of stem cells during
adulthood. The aim of this paper is to investigate the biological characteristics and therapeutic potential of pulp stem
cells derived from primary and permanent teeth. Stem cells extracted from the dental pulp represent a significant
interest in regenerative medicine due to their unique properties and accessibility. Through a comprehensive review
of the existing literature and empirical research, this paper aims to clarify the different qualities of pulp stem cells
from both primary and permanent teeth, exploring their regenerative capacities and therapeutic indications. By
evaluating their potential for differentiation, immunomodulatory effects and clinical applications, this thesis
provides valuable insights into the use of dental pulp stem cells for tissue and regenerative therapies. For the
realization of this paper, we compiled a survey questionnaire that contained several questions for the respondents.
According to the data obtained from a total of 100 respondents, of whom 53 were female and 47 were male. Of the
male population, 47, 17 were medically educated, 30 were medically uneducated. We obtained data that most of
them are not familiar with the procedure. Women are more susceptible with 53%. Despite the significant therapeutic
potential of stem cells dental pulp cells, several challenges remain to be overcome to fully realize their clinical
potential and maximize their impact in regenerative medicine. The application of dental pulp stem cell-based
therapies from preclinical research to clinical applications requires rigorous validation of their safety, efficacy, and
scalability in clinical trials. Collaborative efforts between researchers, clinicians, regulators, and industry partners
are essential to navigate regulatory pathways, secure funding, and advance dental pulp stem cell-based therapies
toward clinical adoption.
Keywords: stem cells, primary teeth, permanent teeth, indications, therapy.