Immunotherapy in treatment of anaplastic thyroid cancer: a case report

This case report describes a 55-year-old woman with diagnosed anaplastic thyroid cancer(ATC).Initially, the patient was treated surgically, followed by rapid progression.After that radiation therapy wasperformed, andthe patient immediately progressesagain.It was decided that the patient should start chemotherapy while waiting for molecular tests due to the rapid growth of the cancer.After six cycles of chemotherapy in which the disease was stable progression occurredagainimmediately after discontinuation of chemotherapy.Molecular test shows PD-L1positive patientwithCPS score of 20% andshe was put on immunotherapy with pembrolizumab.After 1 year of immunotherapy treatment, PET CT scan showedmetabolic and morphological regression of tumor mass in the neck and cervical lymph nodes.The patient had a goodquality of life with no side effects throughout theimmunotherapy.In this case, we want to emphasize that immunotherapy can also be considered as choice of treatmentin anaplastic thyroid carcinomawho represents carcinomaswith high lethalityrate