Association between the presence of odontogenic inflammatory cysts and systemic immune response before and after their surgical therapy

Introduction: Odontogenic inflammatory cysts are pathological lesions that are often represented in clinical practice and they represent potential focal points with an impact on other organs and systems in the body.
Objective: To determinate the association between the presence of odontogenic inflammatory cists and systemic human immune response.
Materials and methods: 63 male and female patients diagnosed with odontogenic inflammatory cysts were included in the study and divided into three groups (Group 1-patients with radicular cysts-23, Group 2-patients with residual cysts-20 and, Group 3-patients with periodontal cysts-20). Тhe values of IgA, IgM and IgG in serum werе examined before and one month after the surgical therapy in the device Cobas 6000 model c501 (Roche, Germany).
Results: In all three investigated parameters of humoral immunity (IgA, IgG and IgM in serum), in the patients IgA values before and 1 month after the intervention between the three groups of patients did not indicate a significant difference for a consequent p=0.4352 vs . p=0.4090. Тhere was not found significant difference for IgG between three groups. The comparison of the three groups of patients regarding the level of IgM in serum indicated a significantly higher value of this parameter in patients before the intervention (p=0.0006) as well as 1 month after the intervention (p=0.0120) and that a significant difference in periodontal compared to residual (p=0.0061)
Conclusion: Surgical intervention of odontogeni inflammatory cysts, cystectomio in toto, affected the values of systemic immunoglobulins, especially the differences in IgM levels. These findings suggest that IgA, IgG,and IgM may play an important role in the occurrence, development, and persistence of cystic lesions
Key words: Odontogenic inflammatory cysts, immunological analysis,systemic immune response, immunoglobulins IgA IgG and IgM.