The role of radiopharmaceutical [99mTc]Tc-MIBI in the evaluation of parathyroid adenoma and osteoporosis in young patients—a case report supporting its integration into standard clinical practice

Bajrami, Ismet and Spahiu, Fakir and Kaçiu, Yll and Janevik-Ivanovska, Emilija and Drakalska, Elena and Stojanoski, Sinisa and Jashari, Armend (2024) The role of radiopharmaceutical [99mTc]Tc-MIBI in the evaluation of parathyroid adenoma and osteoporosis in young patients—a case report supporting its integration into standard clinical practice. In: 21st European Symposium on Radiopharmacy and Radiopharmaceuticals, 18-21 April 2024, Coimbra, Portugal.

	Text Poster Ismet Bajrami EJ (1) (4).pdf Download (705kB)
	Text meeting abstract book-42.pdf Download (368kB)

Abstract

Aim: This study aims to evaluate the sensitivity and specificity of [99mTc]Tc-MIBI as a radiopharmaceutical and parathyroid scintigraphy as a diagnostic tool for identifying parathyroid adenomas.

The patient presented in this paper as a case report can serve as confirmation of the effectiveness of the implementation of this method and supports its integration into our standard clinical practice.

Materials and methods: Data were obtained from a 32-year-old male patient reported to our department with generalized skeletal pain using a SPECT gamma camera and after injection of [99mTc]Tc-MIBI radiopharmaceutical at a dose of 555 MBq.

The patient was first referred to our department for a bone scan. A full body scan showed multiple foci suggestive of metabolic bone disease. A parathyroid scintigraphy was performed which revealed suspected adenoma which with biopsy-confirmed parathyroid adenoma.

Results: The parathyroid scintigraphy revealed the intensive focal accumulation of the [99mTc]Tc-MIBI in the left distal lobe of thyroid grand. The patient undergo surgery—lobectomiam gl. thyroidea lat sin et parathyroidectomiam lat. sin. HP findings were: adenoma glandula parathyroides lat. sin.

The bone pain was stopped after surgery and the level of the parathormone PTH was decreased. The patient recovered after surgery and released from hospital with osteoporotic therapy.

Conclusion: The SPECT camera-based evaluation of patients with recurrent or persistent hyperparathyroidism can provide valuable insights to prevent osteoporosis and other complications associated with untreated parathyroid adenoma. The high sensitivity and specificity of [99mTc]Tc-MIBI scintigraphy, combined with routine preoperative SPECT localization, are increasingly becoming standard practices.

Keywords: Tc99m-MIBI, Scintigraphy, Radiopharmaceutical, Diagnostic tool, Sensitivity

Item Type:	Conference or Workshop Item (Poster)
Impact Factor Value:	4,7
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Elena Drakalska Sersemova
Date Deposited:	12 Dec 2024 11:14
Last Modified:	12 Dec 2024 11:14
URI:	https://eprints.ugd.edu.mk/id/eprint/35123

Actions (login required)

View Item