Izairi, Pranvera and Velickova, Nevenka and Stojovski, Marjan and Izairi, Asim (2022) The Importance of Prenatal Screening of Serum Biomarkers of Quadruple Test and Fetoplacental Unit in the Prediction of Perinatal Risk and Pregnancy Outcome. Acta Medica Balkanica, 7 (13-14). pp. 129-142. ISSN 2545 - 4110 (Print)
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Abstract
Fetal compromise of uteroplacental blood flow leads to utero-placental insufficiency. This study aimed to find a correlation between serum biomarkers from Quadriple test and fetoplacental unit, in the second trimester of pregnancy, as possible predictors for the adverse perinatal outcome.
Material and method: This cohort study was conducted in a SHOG “Mother Theresa”, Skopje, from November 2019 to June
2021. It includes 673 second trimester pregnant women, followed up and monitored till delivery.
Results: From 673 respondents, 523 that is 77.7% made up the control group, while 150 that is 22.3% of pregnant women
made up the examined group. From the examined group, 48 (7.13%) had preeclampsia, 32 (4.75%) had pregnancy-induced
hypertension, 20 (2.97%) had a small fetus for gestational age, and 50 (7.43%) had intrauterine growth retardation.
Discussion: high values of Inhibin A in pregnant women with adverse outcome, statistically was confirmed as significant,
while HCG values were significantly higher in group with preeclampsia. Pregnant women with preeclampsia significantly
more often than pregnant women from control group had higher values of serum AFP, and it wasn’t found significantly
statistical difference in medial values of unconjugated Estriol in four examined groups compared to control group. It was
confirmed the hypothesis that the placental volume by screening in second trimester is important for pregnancy outcome, as well as the flows in uterine and umbilical arteries.
Conclusion: Inhibin A value as a single marker for adverse pregnancy outcome was the best predictor, while the combination of biomarkers from Quadriple test and the uterine arteries flow in the second trimester of pregnancy, represents the best differentiating ability test for pregnant women for adverse and favorable pregnancy outcome.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Nevenka Velickova |
| Date Deposited: | 17 Oct 2024 08:00 |
| Last Modified: | 17 Oct 2024 08:00 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/34852 |
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