Preparation and in vitro stability study of 188Re-HEDP as a bone seeking radiopharmaceutical

Tripunovski, Toni and Mathe, Domokos and Balogh, Lajos and Ugrinska, Ana and Cocevska, Maja (2023) Preparation and in vitro stability study of 188Re-HEDP as a bone seeking radiopharmaceutical. Journal of Morphological Sciences.

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Abstract

The majority of patients with bone metastases will require some kind of therapy for bone pain palliation withtheobjective of improving the quality of live. Bone seeking radiopharmaceuticals emitting beta particles have been used for palliation of bone metastases.Recently,scientists propose a slightly different radionuclide, 188Re that showssuch promise for treating primary and metastatic tumorsas a radiopharmaceutical 188Re-HEDP.188Re-HEDP is a chemical complex of a bisphosphonate ligand with an incorporated atom of radioactive 188Re. Bisphosphonates are ligands that contain the P-C-P bond which makes the molecules resistant to breakdown by enzymatic hydrolysis and are chemically very stable.In this study, we showed the conditions for the labeling of HEDP with 188Re, and the in vitro stability of the radiopharmaceutical complex. 188Re-HEDPis intended for the treatment of patients whose condition often requiresfor the therapeutic dose to be transported to the institution where the patient is hospitalized. Our stability study is performed in order to determine the optimal storage conditions of the radiopharmaceutical if it is not applied to a patient immediately after preparation. The results of radiochemical purity of 188Re HEDP using ITLC quality control technique wasabove 98%. Thestability studyfor 188Re HEDP stored at different ambiental conditions showed that the complex is most stable in the first 3 hours after preparation, if it is stored at +4oC in the dark.It can be concluded that the prescribed preparation conditions (composition and concentration of chemical components, temperature and incubation time) are optimal for the formation of high percentageand stable initial chelating complex of 188Re-HEDP.

Item Type:	Article
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Maja Cocevska
Date Deposited:	17 Jun 2024 12:30
Last Modified:	17 Jun 2024 12:30
URI:	https://eprints.ugd.edu.mk/id/eprint/34290

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