Iron-deficiency anemia as a precursor to cerebral venous sinus thrombosis: A case report

Simeonovska Joveva, Elena and Lichkova, Elena and Petkovska, Marija and Petrovski, Stefan and Karakolevska Ilova, Marija (2024) Iron-deficiency anemia as a precursor to cerebral venous sinus thrombosis: A case report. In: 10th European Stroke Conference (ESOC), 15-17 May 2024, Basel, Switzerland.

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Abstract

Background and aims: : Cerebral venous sinus thrombosis (CVST) poses a rare yet severe
neurological challenge, with multifactorial etiology encompassing prothrombotic conditions, infections,
trauma, medical procedures, hormonal factors, inflammatory disorders, dehydration, malignancies,
and rare inherited disorders. This case report explores the association between iron deficiency anemia
and the development of CVST, shedding light on the non-specific symptoms.
Methods: A 41-year-old female presented with: headache, dizziness, nausea, and vomiting.
Examination revealed impaired consciousness, left-sided hemiplegia, and brisk reflexes. Diagnosis of
CVST was made with computed tomography (CT) and computed tomography angiography (CTA). A
comprehensive assessment, including blood count and iron studies, was conducted to evaluate the
patient's iron-deficiency anemia. The case was initially managed with anticoagulation therapy and two
units of packed red blood cells.
Results: Imaging studies displayed bilateral subarachnoid hemorrhage, intracerebral hematomas, and
a filling defect in the superior sagittal sinus. Laboratory results indicated iron-deficiency anemia and
thrombocytosis. Subsequent CT scans revealed hyperdense hemorrhagic changes, persistent SAH,
and intracerebral hematomas. Physiologically, iron deficiency induces a prothrombotic state through
increased platelet aggregation, alterations in clotting factor function, and impaired fibrinolysis.
Additional links include endothelial dysfunction, elevated homocysteine levels, and reduced nitric
oxide bioavailability.
Conclusions: This case underscores the significance of recognizing iron deficiency as a significant
contributor to a hypercoagulable state in the context of CVST. The interplay of iron in physiological
processes, coupled with its deficiency, heightens the susceptibility to thrombotic events. Recognition
and management of iron deficiency anemia are crucial in mitigating the risk of complications
associated with CVST

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Elena Drakalska
Date Deposited:	11 Jun 2024 08:56
Last Modified:	11 Jun 2024 08:56
URI:	https://eprints.ugd.edu.mk/id/eprint/34264

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