Comparison of the impact of two versions of reagent and ancillary sets on the [18F]FDG radiochemical yield

Kolevska, Katerina and Cocevska, Maja and Atanasova, Marija and Velickovska, Maja and Jolevski, Filip and Razmoska, Jasmina and Ugrinska, Ana (2023) Comparison of the impact of two versions of reagent and ancillary sets on the [18F]FDG radiochemical yield. In: 10th Edition of The Balkan Congress of Nuclear Medicine & 5th Romanian Congress of Nuclear Medicine, 15-18 March 2023, Bucharest.

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Abstract

Aim: The purpose of this study is to compare the impact of the optimised versus standard version of the reagent
set and ancillary kit on the [18F]FDG radiochemical yield.
Materials and Methods: [18F]Fradioisotope is produced in a cyclotron (GE PETtrace 16.5 MeV) by irradiating
enriched 18O water with protons.
[
18F]FDG radiosynthesis (a nucleophilic 18F-fluorination followed by base-catalyzed hydrolysis) is conducted
using an automated synthesizer IBA Synthera V2 module and a single-use disposable system – Integrated Fluid
Processor (IFP) as well as reagents and ancillary set. There are two commercially available versions of these sets.
In the new version of the reagents set, the molar ratio acetonitrile-water in the cryptand solution is 4:1 instead of
1:1. As the separation cartridge in the new version of the ancillary kit is used QMA Carbonate Plus Light, instead
of QMA Plus Light. A modification is also made in the purification cartridges, Oasis HLB in place of the C18
cartridge.
In this study, 100 [18F]FDG batches in total are analyzed. 50 batches were synthesized using the standard version
of the reagent and ancillary kits, while the other 50 batches were with the optimised version.
The mean radiochemical yield (RCY), decay-corrected, and relevant standard deviation (SD) are calculated for
both types of analyzed batches.
Results: [18F]FDG batches produced using the optimised version of reagents and ancillary kit has higher RCY
(65.01% ± 4.52%) compared to the batches produced using the standard version (57.83% ± 3.61%).
Conclusion: This study confirms that the optimisation of the reagent and ancillary sets contributes to a higher
radiochemical yield of the produced [
18F]FDG.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine
Divisions:	Faculty of Medical Science
Depositing User:	Marija Atanasova
Date Deposited:	08 Apr 2024 07:44
Last Modified:	08 Apr 2024 07:44
URI:	https://eprints.ugd.edu.mk/id/eprint/33982

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