COPD as a risk factor for coronary artery disease (CAD): overview of 10-year atherosclerotic cardiovascular disease (ASCVD) risk assessment

Buklioska Ilievska, Daniela and Mickovski, Ivana and Minov, Jordan and Kochovska-Kamchevska, Nade and Hasan, Taner and Baloski, Marjan and Neshovska, Radmila and Nedeska-Minova, Natasha and Prgova-Veljanova, Biljana and Doneva, Daniela and Trajkovska, Vani and Simeonova, Magdalena and Bushev, Jane (2022) COPD as a risk factor for coronary artery disease (CAD): overview of 10-year atherosclerotic cardiovascular disease (ASCVD) risk assessment. In: European respiratory society, International congress 2022, 4-6 Sep 2022, Barcelona, Spain.

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Abstract

We aimed to investigate the association between COPD and CAD (overview of 10-year risk of fatal cardiovascular
event), and the relation to the severity of airflow limitation.
Cross-sectional study including 220 patients with stable COPD as investigated group (IG), aged 40 to 75 years
and 58 non-COPD subjects, matched by gender, age, BMI, smoking status, as control group (CG). All study
subjects underwent pulmonary, cardiological evaluation, lipid and glycemic status.
The analysis compared the 10-year established ASCVD risk between COPD stages (according to GOLD
classification 1, 2, 3, 4) and between IG vs. CG. ASCVD score was classified as low (score <5%), borderline (5 to
<7.5%), moderate (≥7.5 to <20) and high risk (score ≥20%). Results presented statistically significant difference
between mean ASCVD value in IG 21,69±13,86% vs. CG 15,83±9,92% (p=0.0028). The median risk of ASCVD
for fatal cardiovascular events was high in IG and moderate in CG. The mean and median values of 10-year
ASCVD risk in the IG subgroups were: GOLD1 16,79±8,04% (50% of the subjects with risk >15,7%), GOLD2
22,67±16,49% (50% of the subjects with risk >20,6%), GOLD3 26,81±14,15% (50% of the subjects with risk >
27,6%) and GOLD4 20,70±13,52% (50% of the subjects with risk > 18,4%). The average ASCVD risk of fatal
cardiovascular event was moderate in GOLD1 and GOLD4, and high in GOLD2 and GOLD3.
We found higher risk for fatal cardiovascular outcome in patients with COPD, even in the early COPD stages
(GOLD2), compared to non-COPD group. Our findings suggest that an urgent need to develop comprehensive
strategies for prevention, screening and early treatment are needed.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Ivana Mickovski
Date Deposited:	26 Feb 2024 11:24
Last Modified:	26 Feb 2024 11:24
URI:	https://eprints.ugd.edu.mk/id/eprint/33736

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