Graft-versus-host disease in patients treated with allogenic hematopoetic cell transplantation: experience from North Macedonia

Mickovski, Ivana and Buklioska Ilievska, Daniela and Georgievski, Borce and Hasan, Taner and Neshovska, Radmila and Nedeska-Minova, Natasha and Doneva, Daniela (2021) Graft-versus-host disease in patients treated with allogenic hematopoetic cell transplantation: experience from North Macedonia. Acta Haematologica Polonica, 52 (5). pp. 509-515.

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Abstract

Introduction:
Graft-versus-host disease (GvHD) is the major complication arising after allogeneic hematopoietic cell transplantation (allo-HCT). It can be presented as acute and/or chronic GvHD. The purpose of this study was describe the incidence of acute and chronic GvHD in patients treated with allo-HCT.
Materials and methods:
This study was designed as a retrospective study, which included 65 patients treated with allogeneic transplantation from human leukocyte antigen identical donor at University Clinic of Hematology in Skopje, North Macedonia.
Results:
Acute GvHD (aGvHD) was observed in 28 patients, with the most common localization on the skin (75%). Post-transplant phase had significant effect on the frequency of skin aGvHD (p =0.038). Also statistically significant difference was confirmed between patients with and without acute skin GvHD in terms of conditioning regimen (p =0.034). Chronic GvHD (cGvHD) was diagnosed in 10 patients, mostly progressing from the previous acute GvHD (9.23%). Post-transplant phase had also significant effect on the frequency of skin cGvHD (p =0.018). Patients with higher European Society for Blood and Marrow Transplantation risk score had significantly more frequent skin cGvHD than the others.
Conclusions:
Acute and chronic GvHD were one of the main causes of morbidity and mortality of patients after aloo-HCT. GvHD remains a major risk for patients with allo-HCT regardless of diagnosis and type of transplantation.

Keywords
allogeneic transplantation, acute and chronic GvHD, conditioning regimen, donor-recipient match, immune system

Item Type:	Article
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Ivana Mickovski
Date Deposited:	23 Feb 2024 11:57
Last Modified:	23 Feb 2024 11:57
URI:	https://eprints.ugd.edu.mk/id/eprint/33685

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