Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents

Pereska, Zanina and Janicevic-Ivanovska, Danijela and Simonovska, Natasa and Babulovska, Aleksandra and Trajanovska-Spasovska, Aneta and Naumoski, Kiril and Kostadinoski, Kristian (2023) Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents. Archives of Public Health, 15 (2). pp. 47-59.

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Abstract

Initial studies on impaired glucose-insulin homeostasis in heroin dependents have not defined the impact of concomitant hepatitis C infection (HCV), which has been strongly associated with the development of insulin resistance and metabolic syndrome (MS). The aim of our study was to evaluate the association of heroin dependence with glucose-insulin homeostasis disturbances and MS in heroin dependents with HCV seronegativity.
Materials and methods: The study was prospective and cross-sectional, including 160 heroin dependents compared to a control group of 60 participants. MS was diagnosed using International Diabetes Federation criteria. The homeostatic model assessment for insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-%B) were used for assessing insulin resistance and β-cell function of pancreas.
Results: MS was detected in 9.32% of heroin addicts. Heroin dependents with MS compared to dependents without MS were older, had higher BMI, waist circumference and significantly higher systolic and diastolic blood pressure, increased triglycerides (F=8.233, df=2, p<0.001), apoB (F=8.154, df=2, p=0.001), and reduced HDL-C (F=25.926, df=2, p<0.001) and apoA-I (F=16.406, df=2, p<0.001), significantly increased inuslinemia (F=4.928, df=2, p<0.05), insulin resistance-HOMA-IR (F=4,928, df=2, p<0,05) and insignificantly increased pancreatic β-cell function (194.66 ± 224.05) (F=2.461, df=2, p>0.05).
Conclusions: Insulin resistance and МS, independent of HCV, was also registered in heroin dependence. Timely recognition will enable more successful treatment of comorbidities and illicit drug dependence

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Danijela Janikevik
Date Deposited:	19 Feb 2024 18:39
Last Modified:	19 Feb 2024 18:39
URI:	https://eprints.ugd.edu.mk/id/eprint/33522

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