Comparison of the sensitivity of several biomarkers in patients with medication overuse headache (MOH)

Yzeiri Havziu, Drita and Gjorgjeska, Biljana and Bexheti, Dorentina and Haxhiu Zaimi, Arlinda and Shabani, Arijeta and Dauti, Merita and Alili Idrizi, Edita and Gjylaj, Alija and Balashi, Lulzime and Ahmeti Lika, Sihana (2023) Comparison of the sensitivity of several biomarkers in patients with medication overuse headache (MOH). Acta medica Balkanica International Journal of Medical Sciences, 8 (15-16). pp. 126-133. ISSN 2545-4870

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Abstract

Migraine is a common headache disorder that causes significant disabilities. Headache developed or significantly worsened during medication overuse (for simple analgesics and combination acute medications, intake must be 15 days or more per month for triptans, ergotamines, opioids, and combination analgesics; 10 days per month sufficient to get a diagnosis of Medication-overuse headache-MOH). A recent epidemiologic study on drug-induced disorders demonstrated that excessive drug use can lead to nephrotoxicity. Microalbuminuria was common in patients under the influence of nephrotoxic drugs. Subclinical renal damage cannot be identified by routine tests (serum creatinine), and microalbuminuria is a more sensitive indicator of renal dysfunction. The aim is to confirm the sensitivity of certain biomarkers when comparing patients treated with NSAIDs in combination with other drugs (analgesics, triptans and antidepressants) with patients treated with monotherapy by NSAIDs Besides conventional markers of renal functioning (serum/urine creatinine determined by Jaffe methods), enzymatic assay for urea serum and Jon selective electrode (ISE) are used for determination of electrolyte in serum. Imunoturbodimetric assay for determination of urinary albumin, microalbuminuria and β2-microglobulin will be used. In the case of combined therapy with NSAIDs and other medications (analgesics, triptans and antidepressants), a significant effect on the increase of
microalbuminuria has been demonstrated, which signals us for a more sensitive indicator in compared to β2M which as
specific bioindicator did not show a measured sensitivity for the detection of early changes in the tubular level. Significant glomerular damage has been reported in patients with combination therapy than patients treated with NSAID monotherapy. Following the levels of specific biomarkers, we can use them as signals for early detection of nephrotoxicity, especially in patients treated with combination therapy requiring special attention when administering them.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Biljana Gorgeska
Date Deposited:	26 Oct 2023 11:39
Last Modified:	26 Oct 2023 11:39
URI:	https://eprints.ugd.edu.mk/id/eprint/32450

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