Kokoskarova, Pavlinka and Stojanov, Leon and Najkov, Kosta and Ristovska, Natasha and Ruskovska, Tatjana and Skrzypek, Sławomira and Mirceski, Valentin (2023) Square-wave voltammetry of human blood serum. Scientific Reports, 13 (1). p. 8485. ISSN 2045-2322
Full text not available from this repository.Abstract
A study on voltammetric analysis of blood serum diluted in a phosphate buffer is presented using advanced square-wave voltammetry at an edge plane pyrolytic graphite electrode. The results demonstrate that even in a complex medium like human blood serum, electrochemical characterization can be achieved through the use of advanced voltammetric techniques in conjunction with an appropriate commercially available electrode, such as the edge plane pyrolytic graphite electrode, which boosts superior electrocatalytic properties. Without undergoing any chemical treatment of the serum sample, the square-wave voltammetry technique reveals, for the first time, the electrode reactions of uric acid, bilirubin, and albumin in a single experiment, as represented by well-defined, separated, and intense voltammetric signals. All electrode processes are surface-confined, indicating that the edge plane sites of the electrode serve as an ideal platform for the competitive adsorption of electroactive species, despite the extensive chemical complexity of the serum samples. The speed and differential nature of square-wave voltammetry are crucial for obtaining an outstanding resolution of the voltammetric peaks, maintaining the quasi-reversible nature of the underlying electrode processes, while reducing the impact of follow-up chemical reactions that are coupled to the initial electron transfer for all three detected species, and minimizing fouling of the electrode surface.
| Item Type: | Article |
|---|---|
| Impact Factor Value: | 5.516 |
| Subjects: | Natural sciences > Chemical sciences Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Tatjana Ruskovska |
| Date Deposited: | 11 Aug 2023 09:55 |
| Last Modified: | 11 Aug 2023 09:55 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/32020 |
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