Diagnostic and Prognostic Implications of the Oral Exfoliative Cytology in Oral precancer And Cancer Detection

Nikolovski, Bruno and Radojkovska Nikolovska, Vera and Evrosimovska, Biljana and Veleska Stevkovska, Daniela and Zafirova, Biljana and Pejkovska Shahpaska, Budima (2023) Diagnostic and Prognostic Implications of the Oral Exfoliative Cytology in Oral precancer And Cancer Detection. Acta Scientific Dental Sciences, 7 (4). ISSN 2581-4893

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Abstract

Oral cancer is a preventable disease. In 2021, the International Agency for Research on Cancer by World Health Organization,
presents the number of 377713 new cases of oral cancer in 2020, making it the 16th most common malignant disease in the world,
unfortunately with poor prognosis after treatment because of the late stage of the disease [1].
Aim: to explore the accuracy/efficacy, specificity and sensitivity, the positive and negative predicted values of the oral exfoliative
cytology (brush biopsy) as a closest, but less invasive method to the tissue biopsy, respected as a gold standard in the diagnostic
procedures.
Material and Methods: 60 patients divided into two study groups (30 of them with potentially malignant oral lesions and a second
consisted of another 30 patients with previous oral malignant disease) were examined with brush biopsy and underwent to histopathological confirmation - tissue biopsy, selected under certain inclusion and exclusion criteria.
Results: Sensitivity of brush biopsy in the group of examinees with oral potentially malignant lesions is 100%, its specificity is
66.67%, the positive predictive value is 92.31% and the negative predictive value is 100%. The accuracy of the Brush biopsy method
is 93.33%.
The sensitivity, in the group of patients with previous oral malignant disease, is 100%, specificity is 0%, the positive predictive
value is 100% and the negative predictive value is 0%. The accuracy of this method is 100%.
Conclusion: The accuracy reaches a total value of 100% for the group with previous malignant lesions (relapse) and sets the thesis
that brush biopsy as screening method for oral cancer or premalignant tissue changes is enough valuable for the patients with oral
epithelial changes but may be combined with some other type of screening procedures, easy to perform and less invasive ones, in
order to gain relevant results applicable in the everyday clinical practice.
Keywords: Oral Examination; Potentially Malignant Lesions; Oral Cancer; Diagnostics

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Budima Pejkovska Sahpaska
Date Deposited:	01 Jun 2023 07:50
Last Modified:	07 Jun 2023 12:40
URI:	https://eprints.ugd.edu.mk/id/eprint/31844

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