Comparison of oxidative stress levels in healthy children and children with allergic rhinitis

Arnaudova Danevska, Ivana and Jakjovska, Tatjana and Zendelovska, Dragica and Atanasovska, Emilija and Dzekova-Vidimliski, Pavlina and Petrushevska, Marija and Boshkovska, Katerina and Popova, Gorica and Gjinovska Tasevska, Elena and Balkanov, Trajan (2023) Comparison of oxidative stress levels in healthy children and children with allergic rhinitis. Contributions. Sec. of Med. Sci., 44 (1). pp. 17-26. ISSN 1857-9345

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Abstract

Background/aim: Allergic rhinitis (AR) is characterized by chronic inflammation of the nasal mucosa.
Under the influence of exogenous factors - allergens, reactive oxygen species (ROS) are released during
cellular metabolism. They induce a series of pathological changes in the mucosa. Oxidative stress is а result
of an imbalance between the production of ROS and the ability to neutralize them. The aim of this study
is to compare the levels of oxidative stress between healthy children and children with allergic rhinitis.
Material and methods: A total number of 60 children were included (30 healthy children and 30 children
with AR). The oxidative stress index was determined by using the FRAS 5 (Free Radical Analytical System)
Bravo system. Demographic characteristics, medical history, children's living conditions and eating
habits were obtained from the questionnaire. Anthropometric measurements and the absolute number of
eosinophils in the peripheral smear were performed on each child.
Results: This study showed high oxidative stress index and a significantly higher value of the absolute
number of eosinophils in the peripheral smear in children with AR in comparison to healthy children
(p<0.05). The group of children with AR had more atopic characteristics and was more exposed to passive
smoking than healthy children.
Conclusion: Compared to healthy children, children with AR have a high index of oxidative stress, despite
of the very high mean value of the concentration of water-soluble antioxidants in serum (PAT test) in the
group of children with AR.

Item Type:	Article
Uncontrolled Keywords:	allergic rhinitis, children, oxidative stress, d-ROMs, PAT, OSI
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Gorica Popova
Date Deposited:	16 May 2023 08:29
Last Modified:	16 May 2023 08:29
URI:	https://eprints.ugd.edu.mk/id/eprint/31763

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