Electrochemically induced dimerization of lipophilic redox proteins: theoretical insights in protein‑film square‑wave voltammetry

Lazarova, Sanja and Apostoloski, Pavle and Gulaboski, Rubin (2023) Electrochemically induced dimerization of lipophilic redox proteins: theoretical insights in protein‑film square‑wave voltammetry. Monatshefte für Chemie - Chemical Monthly, 154. pp. 1-9. ISSN 1434-4475 (In Press)

Text proof of Electrochem Induced Dimerization in SWV-Lazarova Apostoloski Gulaboski Chemical Monthly April 2023.pdf - Accepted Version Restricted to Repository staff only until 31 December 2026. Download (1MB) | Request a copy

Abstract

Electrochemically induced protein dimerization often happens when two electrochemically generated protein radicals or
other charged protein species come into intimate contact. In such an event, dimers might be created due to hydrogen bonding or because of interactions of uncoupled free electrons in both proteins. The electrochemically induced dimerization process is triggered by the applied potential difference that affects the amount of generated monomeric species. In case of electro�chemically induced dimerization of lipophilic redox proteins, the protein-film voltammetry is a technique of first choice that can provide insight into the mechanistic pathway and can help to get access to kinetic and thermodynamic parameters related to dimerization process. In this work, we applied for the first time the square-wave protein-film voltammetry to study theoretically an electrochemically induced dimerization of strongly adsorbed redox proteins. While important hints are given
to recognize this specific mechanism in square-wave voltammetry, we also propose methodologies to get access to physical parameters relevant to this mechanism.

Item Type:	Article
Impact Factor Value:	1.613
Subjects:	Medical and Health Sciences > Basic medicine Natural sciences > Chemical sciences Natural sciences > Physical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Rubin Gulaboski
Date Deposited:	10 Apr 2023 09:56
Last Modified:	11 Aug 2023 11:28
URI:	https://eprints.ugd.edu.mk/id/eprint/31649

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