Application and future perspective of trichloroacetic acid in the treatment of cervical intraepithelial neoplasia after cold knife conization

Cochkova Morarcalieva, Anita and Ismaili, Bashkim and Velickova, Nevenka and Cochkov, Blaze and Nakova, Marina (2023) Application and future perspective of trichloroacetic acid in the treatment of cervical intraepithelial neoplasia after cold knife conization. Albanian Journal of Medical and Health Sciences, 61 (1). ISSN 2412-6373 / 2413-3892 online

Text 10-Morarcalieva-et-al (1)_230217_161152.pdf - Accepted Version Download (298kB)

Abstract

Background: Factors that contribute to
development of cervical intraepithelial neoplasia
are: age older than 55, and infection with
persistent, high risk Human papillomavirus
(HPV). If the HPV remains in an episomal
nonintegrated state, it results with low grade
lesion and if virus becomes integrated into the
human genome, high grade lesions and cancer
may develop. Low grade lesion is cervical
intraepithelial neoplasia and it refers to mildly
atypical cellular changes in the lower third of the
epithelium. High grade cervical lesions are
cervical intraepithelial neoplasia II and III. CIN
II refers to moderately atypical cellular changes
confined at the basal two thirds of the epithelium
and CIN III refers to severely atypical cellular changes encompassing greater than two thirds of
the epithelial thickness. Cold knife conization
usually is the treatment of choice for high grade
cervical lesions.
Case report: We present a case of new creative
treatment with 85% trichloroacetic acid, of low
grade cervical intraepithelial neoplasia, which
was a residual cervical lesion after a cold knife
conization preformed for high grade cervical
intraepithelial neoplasia grade treatment.
Conclusion: Single topical use of 85%
trichloroacetic acid is an effective treatment for
residual persistent cervical intraepithelial
neoplasia of low grade, after cold knife
conization and provides long term remission and
satisfying Human papillomavirus clearance. Thus 85% trichloroacetic acid treatment can directly
diminish morbidity and mortality of Human
papilloma virus related to precancerous cervical
lesions and cervical carcinoma.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Nevenka Velickova
Date Deposited:	31 Mar 2023 10:46
Last Modified:	23 Aug 2023 09:23
URI:	https://eprints.ugd.edu.mk/id/eprint/31573

Actions (login required)

View Item