Evaluation of factors that effect mobilization and collection of hematopoietic stem cells from peripheral blood

Grubovic Rastvorceva, Rada (2022) Evaluation of factors that effect mobilization and collection of hematopoietic stem cells from peripheral blood. In: International Society for Cell and Gene Therapy Annual Conference 2022, 4-7 May 2022, Moscone Center, San Francisco, USA.

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Abstract

Background & Aim: Mobilization and collection of hematopoietic stem cells (HSC) are the crucial part in the transplantation procedure, with large variations in clinical practice. The aim of the study is to analyze factors that influence mobilization and collection of HSC from peripheral blood (PBSC). Methods, Results & Conclusion: This study was performed in the Institute for Transfusion Medicine of RNM and the University Clinic of Hematology in Skopje. There were 30 allogeneic and 90 autologous donors that underwent mobilization and collection of PBSC. Factors that could influence mobilization and collection of PBSC were analyzed, such as demographic characteristics, laboratory parameters and collection parameters in both groups, and mobilization strategy and clinical characteristics in autologous donors. Results: There was a statistically significant correlation between the total number of collected MNC in autologous donors and platelet count before mobilization, the number of cycles in one apheresis procedure, quantity of collected graft and the number of collected MNC and CD34+ cells on the first day of harvestration. There was a statistically significant correlation between the total number of collected MNC in allogeneic donors and platelet count before mobilization, the number of cycles in one apheresis procedure, quantity of collected graft and number of MNC on first day of harvestration. There was a strong correlation between the number of collected MNC and CD34+ cells on the first harvest and the total number of collected MNC and CD34+ cells in poor mobilizers, and inverse correlation with the number of apheresis procedures. Donors who donated MNC ≤ 0.7x108/kg and/or ≤ 0.7x106/kg CD34+ cells on the first harvest (84.6%) were strong predictors of poor mobilizers. Conclusion: Baseline platelet count is a sensitive indicator of PBSC mobilization in autologous and allogeneic donors. Development of universal guidelines for initiation of apheresis procedure is needed for optimization of mobilization and collection of HSC, as well as for early intervention in poor mobilizers.

Item Type:	Conference or Workshop Item (Poster)
Impact Factor Value:	6.196
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Rada Grubovik Rastvorceva
Date Deposited:	15 Aug 2022 09:40
Last Modified:	15 Aug 2022 09:40
URI:	https://eprints.ugd.edu.mk/id/eprint/30008

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