Plant bioactive compounds affecting biomarkers and final outcome of COVID-19

Gjorgieva Ackova, Darinka and Maksimova, Viktorija and Smilkov, Katarina (2022) Plant bioactive compounds affecting biomarkers and final outcome of COVID-19. Archives of pharmacy, 72 (2). pp. 212-230. ISSN 2217-8767 (On line)

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Abstract

Herbal medicinal products are known for their widespread use toward various viral
infections and ease of disease symptoms. Therefore, the sudden appearance of the Severe
Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) and COVID-19
disease was no exception. Bioactive compounds from natural plant origin could act on
several disease levels: through essential immunological pathways, affecting COVID-19
biomarkers, or by halting or modulating SARS-CoV-2. In this paper, we review the
recently published data regarding the use of plant bioactive compounds in the
prevention/treatment of COVID-19. The mode of actions responsible for these effects is
discussed, including the inhibition of attachment, penetration and release of the virus,
actions affecting RNA, protein synthesis and viral proteases, as well as other mechanisms.
The reviewed information suggests that plant bioactive compounds can be used alone or
in combinations, but upcoming, extensive and global studies on several factors involved
are needed to recognize indicative characteristics and various patterns of bioactive
compounds use, related with an array of biomarkers connected to different elements of
inflammatory and immune-related processes of COVID-19 disease.

Item Type:	Article
Subjects:	Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Darinka Gorgieva Ackova
Date Deposited:	16 May 2022 08:38
Last Modified:	16 May 2022 08:38
URI:	https://eprints.ugd.edu.mk/id/eprint/29754

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