Yzeiri Havziu, Drita and Gjorgjeska, Biljana and Miftari, Visar and Alili Idrizi, Edita and Alija, Gjylaj and Haxhiu Zaimi, Arlinda and Dauti, Merita and Ahmeti Lika, Sihana and Balazhi, Lulzime (2021) Migraine and the effects of NSAIDS on renal function. III. International Başkent Congress on Physical, Social and Health Sciences Proceedings Book.
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Abstract
Trigeminovascular system (TGV) activation is a basic mechanism for generating pain during a migraine attack. Many experimental results highlight the importance of the cyclooxygenase system in the peripheral arm of TGV and suggest that NSAIDs may be effective in migraine therapy through the action of these peripheral nociceptors. Inhibition of NSAID-mediated prostaglandin synthesis prevents neurogenically mediated inflammation of the trigeminal system and reduces pain, but at the same time
inhibition of prostaglandin in the kidney may reduce renal blood flow,speed glomerular filtration retention. and water. The purpose of the study is to follow the renal function, in patients with cefaleamigraine that has been treated for a long period, treated with Diclofenac and Paracetamol.We used Jaffe’s method for the determination of serum/urine creatinine and еnzymatic assays for urea and uric acid in serum and ᵧ glutamyl transferase (ᵧ-GT) in serum and jon selective electrode (ISE) are used for determination of electrolite in serum. We used nephelometry by β2 microglobulin (β2M) and photoelectric colorimetry for microalbuminuria in urine, to monitor glomerular and tubular functioning. Any history of kidney diseases was exclusion criteria to enter the study. In chronic treatment of patients with headache with Diclofenac and Paracetamol in symptomatic headaches, they have been confirmed as renoprotective in their use.
Keywords: non-steroidal anti-inflammatory drugs, migraine, renal function, trigeminovascular system
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Biljana Gorgeska |
| Date Deposited: | 29 Dec 2021 10:12 |
| Last Modified: | 30 Dec 2021 08:32 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/28976 |
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