Martin, John and Sykes, Sean and Young, Sarah and Kota, Karthik and Sanka, Ravi and Sheth, Nihar and Orvis, Joshua and Sodergren, Erica and Weinstock, George M and Mitreva, Makedonka and Wang, Zhengyuan (2012) Optimizing read mapping to reference genomes to determine composition and species prevalence in microbial communities. PLoS One, 7 (6). e36427.
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Abstract
The Human Microbiome Project (HMP) aims to characterize the microbial communities of 18 body sites from healthy
individuals. To accomplish this, the HMP generated two types of shotgun data: reference shotgun sequences isolated from different anatomical sites on the human body and shotgun metagenomic sequences from the microbial communities of each site. The alignment strategy for characterizing these metagenomic communities using available reference sequenceis important to the success of HMP data analysis. Six next - generation aligners were used to align a community of known composition against a database comprising reference organisms known to be present in that community.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Mirjana Kocaleva Vitanova |
| Date Deposited: | 03 Dec 2012 11:48 |
| Last Modified: | 03 Dec 2012 11:48 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/2882 |
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