Bcl-2 and Ki67 as specific prognostic markers in estrogen receptor positive breast cancers

Jasar, Dzengis and Filipovski, Vanja and Kubelka-Sabit, Katerina (2017) Bcl-2 and Ki67 as specific prognostic markers in estrogen receptor positive breast cancers. Virchows Archiv, 471. S54-S54. ISSN 1432-2307 (electronic version) Journal no. 428

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Official URL: https://www.springer.com/journal/428

Abstract

Objective: Breast cancer is a heterogeneous disease, so many biomarkers can be potential predictors in its outcome. The aim of this study is to test the hypothesis that combinatorial assessment of both Ki-67 proliferation index and B-cell Lymphoma 2 (Bcl-2) protein, would provide prognostic information on occurrence of relapses in breast cancer patients.

Method: Immunohistochemical expression of Ki67 and Bcl-2, represented as Ki67/Bcl-2 index, were evaluated in 183 Estrogen Receptor positive breast cancer patients from 2007 to 2012, compared with other clinical-pathologic findings. During the follow up period (45–114 months) recurrences were observed in 36 patients (19.7 %).

Results: A significant correlations were notified between Ki67/Bcl-2 index with age, tumour size, nuclear grade, histologic grade, lympho-vascular invasion, progesterone receptor status and expression of p53 protein product (p < 0,05). The occurrence of relapses in the group of low Ki67/high Bcl-2 index was lower, compared with the group of high Ki67/low Bcl-2 index breast cancer patients (p < 0.01).

Conclusion: The combination of Ki67 and Bcl-2 biomarkers is useful tool in prediction of relapses in Estrogen positive breast cancer patients.

Item Type:	Article
Impact Factor Value:	2.848
Uncontrolled Keywords:	breast cancer, prognostic markers, bcl-2, Ki67
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Vanja Filipovski
Date Deposited:	06 Dec 2021 08:21
Last Modified:	06 Dec 2021 08:21
URI:	https://eprints.ugd.edu.mk/id/eprint/28667

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