Improvement of Chronic Spontaneous Urticaria with Levothyroxine and Autohemotherapy (A case report)

Trajkova, Vesna and Velickova, Nevenka and Breshkovska, Hristina (2021) Improvement of Chronic Spontaneous Urticaria with Levothyroxine and Autohemotherapy (A case report). Medicus, 26 (2). pp. 257-260. ISSN 1409-6366

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Abstract

Chronic spontaneous urticaria (CSU) is a mast cell-driven skin disease characterized by the recurrence of transient wheals, angioedema, or both for more than 6 weeks. Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. CSU can improve in response to treatment with levothyroxine or other thyroid drugs. Some studies revealed that notably autologous serum skin test (ASST)-positive CSU patients may benefit from autohemotherapy; however, the mechanisms of action remain unknown. We presented a case of a patient suffering from CSU with angioedema, positive ASST test and a newly diagnosed Hashimoto’s thyroiditis in which levothyroxine in combination with autohemotherapy completely resolved the symptoms of urticaria. Laboratory investigations showed a high thyroid stimulating hormone (TSH) level and a normal free thyroxine (T4) level. She had elevated levels of antithyroid peroxidase (anti-TPO) and raised lever of free thyroxine (T3) , Thyroid peroxidase antibody test ( Anti TPO). She was diagnosed as a case of Hashimoto's thyroiditis and started on levothyroxine therapy and autohemotherapy. She noticed that her uncontrolled recurrent urticaria started to get better and after a few months of therapy, she stopped taking her topical ointments and antihistamines.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Nevenka Velickova
Date Deposited:	08 Oct 2021 09:18
Last Modified:	08 Oct 2021 09:18
URI:	https://eprints.ugd.edu.mk/id/eprint/28535

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