Ruskovska, Tatjana and Budic-Leto, Irena and Corral-Jara, Karla Fabiola and Ajdzanovic, Vladimir and Arola-Arnal, Ana and Bravo, Francisca Isabel and Deligiannidou, Georgia-Eirini and Havlik, Jaroslav and Janeva, Milkica and Kistanova, Elena and Kontogiorgis, Christos A. and Krga, Irena and Massaro, Marika and Miler, Marko and Milosevic, Verica and Morand, Christine and Scoditti, Egeria and Suárez, Manuel and Vazour, David and Milenkovic, Dragan (2021) Systematic bioinformatic analyses of nutrigenomic modifications by polyphenols associated with cardiometabolic health in humans—Evidence from targeted nutrigenomic studies. Nutrients, 2021 (13). p. 2326.
Full text not available from this repository.Abstract
Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
| Item Type: | Article |
|---|---|
| Impact Factor Value: | 5.717 |
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Health sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Tatjana Ruskovska |
| Date Deposited: | 10 Aug 2021 10:40 |
| Last Modified: | 10 Aug 2021 10:40 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/28315 |
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