Petrovski, Mihajlo and Minovska, Ana (2021) Analysis of early phase wound healing after Er: YAG laser assisted periodontal pocket debridement. Knowledge – International Journal, 45 (4). pp. 803-809.
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ANALYSIS OF EARLY PHASE WOUND HEALING AFTER ER YAG LASER ASSISTED PERIODONTAL POCKET DEBRIDEMENT.pdf Download (393kB) |
Abstract
The main effect of pocket debridement in periodontology is a tissue wounding followed by phases of healing. Complex chemically mediated amplification cascade is responsible for the beginning and control of the inflammatory response that can be activated by numerous events. The chemical mediators that have active contribution to this process are numerous. Main aim of this study was to make comparative histomorphometrical analysis of healing after soft tissue wall debridement on the periodontal pocket with (1) an erbium laser using low energy levels and with (2) conventional manual instrumentation in order to examine marker proteins during early stage of wound healing. Total number of 15 subjects with diagnosed chronic periodontitis and loss of attachment bigger than 5 mm on one side of the tooth were included in the study. Every patient was primarily treated with supra gingival removal of the dental plaque and calculus using an ultrasonic device and removal of all local irritating factors (if it’s necessary). That was done in order to create an adequate condition for improving the oral hygiene. This was followed by subgingival "non-surgical debridement" using conventional- mechanical versus laser assisted treatment. During laser assisted treatment were used following energy parameters: for soft tissue, energy density is about 178 mJ / mm2 and 256 mJ /mm2 . The biopsy was taken from the soft tissue wall of the periodontal pocket, 24 and 72 hours after periodontal treatment and these marker proteins were assessed: myeloperoxidase, vimentin, CD34 and CD68. The results from this study showed that subjects treated with conventional method using hand instruments compared with the group of patients treated with laser after 24 hours have significant differences (p <0.001) for all marker proteins. Also, similar results were obtained in the bioptical materials taken after 72 hours. Only the results for CD34 showed a significant difference (p <0.001) for the laser assisted treatment group compared to the results from conventional manual instrumentation. Early stage of wound healing after low energy erbium laser assisted periodontal treatment was characterized by relatively reduced marker proteins in context of early phase wound healing for myeloperoxidase, vimentin and CD68, but with a higher expressed value for CD34. Most likely, these values for CD34 are related to minimally invasive periodontal pocket instrumentation and to the very narrow zone of soft tissue thermal damage. Thеse results can be interpreted as a positive sign for the direction of the appropriate cell types to the inflammation area in a timely manner. But at the end, it must be noted that numerous facts are still needed to further clarify the biological mechanism of healing after the application of the low energy Er: YAG laser irradiation before the understanding of this complex is completed.
Keywords: Low-energy ER: YAG laser, early phase wound healing, laser assisted pocket debridement, marker proteins.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Mihajlo Petrovski |
| Date Deposited: | 12 May 2021 06:57 |
| Last Modified: | 12 May 2021 06:57 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/28071 |
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