Duvlis, Sotirija and Dabeski, Drage and Predrag, Noveski and Ljube, Ivkovski and Dijana, Plaseska-Karanfilska (2020) Association of IL-10 (rs1800872) and IL-4R (rs1805010) polymorphisms with cervical intraepithelial lesions and cervical carcinomas. JBUON, 25 (1). p. 1107.
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Abstract
Summary
Purpose: Genetic characteristic of cytokines may influence
cervical intraepithelial neoplasia (CIN) and cervical cancer
(CCa) susceptibility. We analysed an association of IL-10-
592 A/C, IL-4R I75VA/G polymorphisms with susceptibility
to human papillomavirus (HPV) positive CIN and CCa.
Methods: Using multiplex PCR- SNaPShot analysis, 134
cases (HPV positive CINs and CCa) and 113 controls (HPV
negative NILM) were genotyped for these two cytokine
variants.
Results: Data analyzed using odds ratio (OR) and chisquare (x2
) test showed that the frequency of CC of IL-10-592
genotype was significantly higher in cases (67.2%) than in
controls (49.6%) [CC vs CA+AA; p=0.005, OR=2.08 (95%CI:
1.24-3.49)] as well as the allelic frequency of major C allele
(82.1%) in cases than in controls (72.6%) [p=0.01, OR=1.73
(95%CI: 1.13-2.66)]. Furthermore, AA genotype of IL-4RI75V
had significantly lower frequency in CIN1 (25.0%) compared
with CIN2+ group (30.8%) (p=0.03, OR=0.39, 95%CI: 0.14-
1.11) after the stratifications of the cases in low grade and
high grade with CCa as separate groups.
Conclusion: We concluded that IL-10-592 A/AA variant
indicates a protective role in cervical cancer development and
the GG genotype of IL-4RI75V conferred protection against
progression of CIN1 to CIN2+ or CCa among women from
Republic of North Macedonia.
Key words: cervical can
| Item Type: | Article |
|---|---|
| Impact Factor Value: | 1.38 |
| Subjects: | Medical and Health Sciences > Basic medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Sotirija Duvlis |
| Date Deposited: | 19 May 2021 08:25 |
| Last Modified: | 19 May 2021 08:25 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/27494 |
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