Ye, Liang and Hillier, LaDeana W and Minx, Patrick and Thane, Nay and Locke, Devin P. and Martin, John and Chen, Lei and Mitreva, Makedonka and Miller, Jason R and Haub, Kevin V and Dooling, David J and Mardis, Elaine and Wilson, Richard K. and Weinstock, George M and Warren, Wesley (2011) A vertebrate case study of the quality of assemblies derived from next-generation sequences. Genome Biology, 12 (3). pp. 1-7.
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Abstract
The unparalleled efficiency of next-generation sequencing (NGS) has prompted widespread adoption, but
significant problems remain in the use of NGS data for whole genome assembly. We explore the advantages and
disadvantages of chicken genome assemblies generated using a variety of sequencing and assembly methodologies. NGS assemblies are equivalent in some ways to a Sanger-based assembly yet deficient in others. Nonetheless, these assemblies are sufficient for the identification of the majority of genes and can reveal novel sequences when compared to existing assembly references.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Mirjana Kocaleva Vitanova |
| Date Deposited: | 30 Nov 2012 15:13 |
| Last Modified: | 10 Jun 2013 09:02 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/2671 |
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