Dimitrovska Ivanova, Marija and Zisovska, Elizabeta (2020) Evaluation of breast milk sIgA protective role versus alpha glutathione S transferase in infants acute gastroenteritis. Physioacta: Journal of Macedonian Association of Physiologists and Anthropologista, 14 (1). pp. 77-90. ISSN 1857-5587
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Abstract
Aim: The aim of this study was to assess whether mucosal integrity measured by stool sIgA values is a protective factor against epithelial damage measured by serum α-GST values in infants with acute gastroenteritis and their association with the type of nutrition.
Material and Methods: A total of 23 infants with acute gastroenteritis divided in 2 groups based on the feeding patterns (type of milk) were included in the study. Investigated indicators were severity of symptoms, dehydration degree and the need for parenteral rehydration. Stool sIgA and serum α-GST levels were tested and compared between the groups.
Results:A statistically significant association was identified betweengroup affiliation and the sIgA levels in stool (p=0.001346). The most common cause of acute gastroenteritis in infants was Rotavirus. Our study has shown that exclusive breastfeeding reduces the risk of Rotavirus infection especially in the first 6 months of life OR=0.0758, 95%CI(0.0071-0.8074). It was found a statistically significant association between group affiliation and the α-GST levels in serum (p=0.002260). It was revealed that Rotavirus can cause erosion of the intestinal epithelium through the positive values of α-GST in Rotavirus positive cases. It was found that stool sIgA negatively correlates with serum α-GST for p=0.002.
Conclusion: Breastfeeding is important, especially in the first two years of a child’s life, because breast milk provides high concentrations of sIgA that protects the intestinal epithelium of infants from damage in the presence of intestinal pathogens, as in this case it protects it from damage caused from Rotavirus acute gastroenteritis.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Marija Dimitrovska |
| Date Deposited: | 18 Aug 2020 08:50 |
| Last Modified: | 18 Aug 2020 08:50 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/24338 |
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