Gulaboski, Rubin and Mirceski, Valentin and Lovrić, Milivoj (2020) SURFACE CE Mechanism-Model for Analyzing Chemical Interactions and Electrochemical Behavior of Lipophilic Drugs and Enzymes-MATHCAD Simulation Protocol. [Dataset] (Unpublished)
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Abstract
Surface reaction of dissociation of an electrochemically inactive compound „A” can generate surface (adsorbed) reactive species “Ox” that can undergo electron transfer at the working electrode surface. If all participants of the electrode reaction are strongly adsorbed at the working electrode surface, we designate this mechanism as a SURFACE CE Mechanism. The reaction scheme of this mechanism met in many physiological systems and enzymes, is as follow
A(adsorbed) --> Ox(adsorbed) + ne- = Red(adsorbed)
We assume a reversible chemical step and kinetically controlled quasi-reversible electrochemical step.
SW voltammograms of this particular mechanism are function of the electron transfer parameters related to the electrode reaction, but they also depend on the kinetic and thermodynamic parameters linked to the preceding chemical step. The entire interplay of all parameters leads to very specific voltammograms, whose feature can reveal important kinetic and thermodynamic parameters relevant to the physiological systems of interest. Electrode transformation of many transient metal ion, drugs, lipophilic enzymes, fat-soluble vitamins and lipophilic metal-Ligand complexes follow this pathway. We provide the readers methods on how to access all thermodynamic and kinetic parameters relevant for this particular mechanism.
Part of the results related to this mechanism are published in our paper Electrochem. Commun. 7 (2005) 515-522 .
| Item Type: | Dataset |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Natural sciences > Chemical sciences Natural sciences > Computer and information sciences Natural sciences > Matematics Natural sciences > Physical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Rubin Gulaboski |
| Date Deposited: | 05 Apr 2020 20:34 |
| Last Modified: | 05 Apr 2020 20:34 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/23966 |
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