Kamceva, Gordana (2019) Relationship between erytrocyte and plasma concentration of malondialdehyde in patients with coronary artery disease. Knowledge – International Journal. ISSN 2545-4439
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KNOWLEDGE – International Journal Vol.34.4 September, 2019, pages 1-18, 113-121.pdf Download (5MB) | Preview |
Abstract
Introduction: The oxidative stress contributes for the development of the atherosclerosis and leads to instability of the atheromatous plaque in the vascular wall. The serum biomarkers of lipid peroxidation, such as malondialdehyde, may represent an independent indicator of risk for patients with coronary artery disease (CAD).
Aim: To be examined if there is a difference in the erythrocyte and plasma concentrations of thiobarbituric acid (Thiobarbituric acid reactive supplements, TBARS) degradable lipid peroxidation products, expressed through a concentration of malondialdehyde (MDA) between patients with coronary artery disease and healthy blood donors.
Material and methods: The examination represents a cross – sectional study involving 300 patients, divided in two groups: patients with an acute coronary artery disease and a chronic (ischemic) heart disease, divided into appropriate subgroups. The specimens processed in the biochemistry laboratory and it was used spectrophotometric test for quantitative determination of malondialdehyde in blood plasma and for an interpretation of the results standard reference values are used.
Results: The results indicate statistically significant difference regarding the mean values of malondialdehyde concentration in the patients with and without coronary artery disease. There was no statistically significant difference between those with an acute and with a chronic coronary artery disease, althougt higher concentrations were observed in patients in the acute coronary artery disease than in the patients with the chronic (ischemic) coronary artery disease group. Statistical analysis of the data showed that there was also a statistically significant difference in mean values of malondialdehyde (MDA) concentration between subjects in the acute CAD group: between patients with STEMI and NSTEMI (p = 0.0237) and between patients with APNS and NSTEMI (p = 0.0164), and no statistically significant difference was found between the subjects in the chronic CAD group.
Conclusion: The results of the performed research indicate to an increased level of malondialdehyde in the blood plasma at the patients with a coronary artery disease that indicates an existence of a redox imbalance compared with healthy patients. It is necessary, in future, these analyses to be used as a part of the panel of already known and/or new biomarkers with a goal appropriately to act toward the prevention or a certain treatment when curing patients with CAD, especially in patients with acute CAD.
Key words: malondialdehyde, oxidative stress, coronary artery disease
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Gordana Kamceva |
| Date Deposited: | 08 Nov 2019 12:06 |
| Last Modified: | 08 Nov 2019 12:06 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/22798 |
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