Aleksandrov, Mihail and Maksimova, Viktorija and Koleva Gudeva, Liljana (2019) Review of the Anticancer and Cytotoxic Activity of some Species from Genus Euphorbia. Agriculturae Conspectus Scientificus, 84 (1). pp. 1-5. ISSN 1331-7776
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Abstract
Euphorbiaceae family is widely spread family that contains more than 2000 species in the genus Euphorbia. The plants of this genus have been used for a long time in traditional medicine. Their main active components: alkanes, triterpenes, phytosterols, tannins, polyphenols and flavanoids are supposed to be responsible for different types of activity. Euphorbia formosana Hayata is a medicinal plant used to treat: rheumatism, liver cirrhosis, herpes zoster, along as tumor suppressor. Euphorbia tirucalli L. have been used to obtain methanolic extracts. Their cytotoxic activity have been examined against many different types of cancer cells, as well as: colon cancer cell line, liver cancer cell line, ovarian cancer cell line and prostate cancer cell line. Leukemic cell lines, THP-1 and HL-60, have been inhibited in a dose dependent after 24h of treatment with 400μg/mL Euphorbia formosana Hayata. In vitro anticancer activity assays of Euphorbia formosana Hayata suggest potent anticancer effects that cause both cell cycle arrest and apoptosis of leukemic cancer cells. The ethanolic extract of Euphorbia helioscopia L. inhibited the growth of only three cancer cell lines, Hep-2 (27%), T-47D (7%) and PC-5 (11%). Cell viability assays were conducted on the pancreatic cancer primary tumor cell line to assess the relative toxicity of the Euphorbia tirucalli L. extracts. The toxicity of both extracts was found to be dose dependent, with cell viability decreasing with increasing extract concentration. Both aqueous and methanol extracts demonstrated similar activity at 50μg/mL with a viability of 50%, while only the methanol extract exerted a significant decrease in cell viability from 25μg/mL. The pronounced cytotoxic activity of this very few species from the genus Euphorbia, suggest that it could be very interesting to investigate more deeply about their potent anticancer ability. So, the aim of this study was to make a review of the anticancer activity of some of the species examined experimentally by now, using different in vitro or in vivo assays.
Key words: anticancer effects, cytotoxic effects, Euphorbia spp., medicinal plants.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Health sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Liljana Koleva Gudeva |
| Date Deposited: | 28 Mar 2019 09:15 |
| Last Modified: | 28 Mar 2019 09:15 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/21844 |
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