Influence of Lovastatin and combined antioxidant therapy on oxidative status parameters

Ruskovska, Tatjana and Dimovska, Jordanka and Georgieva, Borjanka and Nikolovski, Atanas (2006) Influence of Lovastatin and combined antioxidant therapy on oxidative status parameters. XIII Congress of the Society for Free Radical Research International.

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Abstract

We investigated the effect of lovastatin (20 mg/day, during 6 weeks) on oxidative status parameters in 30 patients with severe dyslipidemia. There was considerable improvement of lipid status and significant improvement of oxidative status parameters (serum hydroperoxides, TAOS and anti-oxLDL). We also investigated the influence of combined antioxidant therapy (500 mg/day vitamin C and 100 mg/day vitamin E) in 20 patients on hemodialysis. In these patients, there was no change of lipid status parameters, while serum hydroperoxides significantly dropped down for 69.5%. TAOS did not change significantly, probably because of the influence of uremia itself. Finally, anti-oxLDL also did not change significantly, suggesting that its lowering is probably connected with lowering of LDL or with use of some other kind of antioxidant therapy.

Item Type:	Article
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Tatjana Ruskovska
Date Deposited:	24 Nov 2012 16:18
Last Modified:	24 Nov 2012 16:18
URI:	https://eprints.ugd.edu.mk/id/eprint/1925

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