Smilkov, Katarina and Gjorgieva Ackova, Darinka (2017) Emerging drug delivery systems of anticancer agents: exosomes. In: Second International Scientific Conference of the Faculty of Medical Sciences - SISCFMS 2017, 13-14 Oct 2017, Tetovo, Macedonia.
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Abstract
Several properties of exosomes make them potential drug delivery systems, especially the fact that they can be regarded as natural liposomes. Their endogenous origin and potential of reduced side effects and targeted action make them more attractive to researchers worldwide. Since this new technology of implementation of exosomes as drug carriers is just emerging, several authors presented incorporation of anticancer agents into exosomes. Namely, for this purpose, curcumin has been used, thus reportedly resulting with curcumin-loaded exosomes that presented increased solubility, stability, and bioavailability, and its’ increased delivery to activated monocytes. Doxorubicin has also been incorporated into exosomes, resulting in its specific delivery to tumor tissues, and leading to inhibition of tumor growth in tumor-bearing nude mice model. In addition, paclitaxel has also been investigated for incorporation in exosomes using different techniques, reportedly showing increased cytotoxicity more than 50 times in drug resistant MDCKMDR1 (Pgp+) cells and nearly complete co-localization of airway-delivered exosomes with cancer cells in murine model of pulmonary cancer metastases. Other types of cargos have also been loaded to exosomes and explored, mostly of different RNA type.
These researches, along with the constant growth of the articles published in this field, leave no doubt that, exosomes as drug delivery systems have big potential to be considered in the development of new anticancer drugs
| Item Type: | Conference or Workshop Item (Speech) |
|---|---|
| Subjects: | Natural sciences > Biological sciences Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Engineering and Technology > Nano-technology Engineering and Technology > Other engineering and technologies Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Katarina Smilkov |
| Date Deposited: | 26 Jan 2018 11:46 |
| Last Modified: | 26 Jan 2018 11:46 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/19115 |
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