Aleksandrov, Mihail and Maksimova, Viktorija and Gulaboski, Rubin (2017) Evaluation of the redox interaction of rutin with some medicinal substances by cyclic voltammetry. In: 17th International Symposium and Summer School on Bioanalysis, 2-8 July 2017, Ohrid, Republic of Macedonia.
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Abstract
Rutin is one of the most frequently represented flavonoid glycoside found in
many plants commonly used in nutrition or herbal preparations. Due to its polyphenolic
structure, it could be easily subjected to redox reactions, which allows its analysis by
different electrochemical methods.
The aim of this study was to evaluate the interactions between rutin and certain
medicinal substances, as a potential food-drug interaction, after consuming them in the
same time. These interactions can also lead to some synergistic or antagonistic
physiological effects. The interactions between rutin and lorazepam, diazepam, alfalipoic
acid, glimepiride, acetylsalicylic acid and ascorbic acid, have been evaluated by
application of an electrochemical analysis by the means of cyclic voltammetry. The
experiments have been performed on a glassy carbon electrode as working electrode and
potential range from -0.4 to 0.6 V. The obtained results were used further for calculation
of the kinetic of these reactions by implementing the characteristic parameters from
cyclic voltammograms in a specially designed theoretical models. The estimated values
of the chemical rate constants for the interactions between rutin and the investigated
compounds read (in mol-1 L s-1): 0.0025, 0.0022; 0.0024; 0.0020; 0.0550 and 0.0620 for
lorazepam, diazepam, lipoic acid, glimepiride, acetylsalicylic acid and ascorbic acid,
respectively.
From the obtained results, we can conclude that the highest interaction have been
noted between rutin and ascorbic acid. These data can serve into prospecting their in
vivo interactions.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Natural sciences > Chemical sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Viktorija Maksimova |
| Date Deposited: | 18 Oct 2017 09:24 |
| Last Modified: | 18 Oct 2017 09:24 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/18278 |
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