Gjorgjeska, Biljana and Petkovska, Sofija and Koneva, Violeta (2016) Comparison of Dissolution Test for Metronidazole Tablets in International and American Pharmacopoeia. In: First International Students’ Symposium of Faculty of Medical Sciences CELEBRATING ACHIEVEMENTS IN MEDICINE, PROMOTING HEALTH AND SHARING KNOWLEDGE, 20 Apr 2016, Stip, Macedonia.
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Abstract
The tablets are commonly used dosage forms and as such are subject to tests to prove their quality. As inevitable here is the test that determine dissolution of active component from the tablet. Over the years the test suffered a series of improvements. At the end it become an official test in pharmacopoeias and mandatory testing for tablets quality. Depending on the properties of the active ingredient, pharmaceutical form and effect of the drug used specific standardized equipment, appropriate medium, and method of analysis is proscribed in pharmacopoeia monographs.
The purpose of this paper was to make a comparison of the tests for metronidazole tablets in official monographs in International Pharmacopoeia and US Pharmacopoeia in order to determine similarities and differences.
Comparison of monographs in both pharmacopoeias was made in terms of apparatus used, the medium, the speed of rotation of the apparatus and the tolerances allowed when performing the test.
Although the dissolution test prescribed in general part of both pharmacopoeias is the same, in the individual monographs the visible differences exist in terms of the prescribed equipment, medium, speed and tolerance.
It can be concluded that the dissolution test of active component in metronidazole tablets is an important parameter for testing the quality, despite the differences that exist in performing the test in various pharmacopoeias. Using the dissolution test in routine control of the production process proves compliance with the required quality of each batch produced. This is particularly important in terms of ensuring the quality of medicines and meeting the standards of good manufacturing practice.
Keywords: apparatus, dissolution test, International Pharmacopoeia, European Pharmacopoeia, US Pharmacopoeia
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Biljana Gorgeska |
| Date Deposited: | 27 Sep 2016 09:09 |
| Last Modified: | 27 Sep 2016 09:09 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/16308 |
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