Gurzanova-Dunev, Liljana and Zisovska, Elizabeta and Zendelovska, Dragica and Dimitrova Sumkovska, Jasmina (2015) Expressions of oxidative injury markers in preterm infants during the first postnatal week. Книга со трудови од Шести Конгрес на Здружението на педијатрите со интернационално учество. pp. 92-94.
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Abstract
Background: Oxygen free radical injury is implicated as a major factor in the
pathogenesis of the long term complications seen in premature infant. The purpose of this
study was to determine whether protein and lipid oxidation products can serves as useful
markers for assessing oxidative stress in preterm babies who subsequently developed
chronic lung disease, with immature lungs being particularly sensitive to the injurious
effect of oxygen and mechanical ventilation
Material and Methods: Мarkers of potential oxidative risk: protein carbonyls and
malondialdehyde (MDA) and antioxidant activity of glutathione peroxidase (GPx) were
measured in blood samples, obtained at 1, 3 and 7 days from 104 preterm babies divided
in: control group (healthy preterm babies, n=59) and CLD group (preterm babies who
subsequently developed CLD, n=45).
Results: Evaluation of the results, during the first 7 days of life, showed permanent
rise in serum concentrations of MDA (
p<0.001) and protein carbonyls (days 1–3, p=0.044
and 4–7,
p<0.001) accompanied by a simultaneous significant decrease in the erythrocyte
activity of GPx (days 1–3,
p=0.028 and 4–7, p<0.001). CLD group had significantly higher
MDA concentrations than controls at day 3 (93%, p<0.001) with highest registered level at
day 7 (4.55±0.92 nmol/ml,
p<0.001) and significantly higher protein carbonyls at any time
(
p<0.001). GPx activity was significantly lower in CLD group at day 7 (54 %, p<0,001)
compared with controls. A strong negative correlation was found between MDA and protein
carbonyls with GPx activity (
r=0.727, p<0.001 and r=0.736, p<0.001, respectively) in the
CLD group.
Conclusion: Oxidatively modified molecules are appropriate for assessing oxidative
stress in vivo. The presence of oxidant/antioxidant imbalance during the first days of life
provides evidence that increased oxidative stress plays a role in the development of
chronic lung disease (CLD).
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elizabeta Zisovska |
| Date Deposited: | 17 Nov 2015 14:02 |
| Last Modified: | 17 Nov 2015 14:02 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/14269 |
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