Gurzanova Durnev, Liljana and Djosic Markovska, Bozidarka and Zisovska, Elizabeta and Zivkovic, Jadranka and Stafilov, Trajče and Zendelovska, Dragica (2011) Inadequate antioxidant protection in preterm babies: possible cause for hyperbilirubinemia. Biologia Macedonia (62). pp. 55-64. ISSN 1857-5277
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Abstract
Many illnesses in pre-term infants are thought to be related to the action of reactive oxygen species
and it is conceivable that the oxidants play a certain role in the etiopathogenesis of unconjugated hy-
perbilirubinemia. We hypothesized that an important factor in the mechanism of oxidative injury in
hyperbilirubinemic infants on the first day of life would be increased oxidative stress in relation to
antioxidants.
For this aim, 43 pre-term infants as well as full-term healthy reference group (A=50) were subjected
in the present study. Additionally, pre-terms were divided in: healthy pre-terms (B=25) and hyperbilirubinemic
pre-terms (C=18). Perinatal variables (gestational age, birth weight and Apgar
score)
were
recorded, and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx)
activity
and selenium (Se) levels were measured in umbilical cord blood, immediately after the delivery.
The obtained results indicate strikingly lower antioxidant capacity of pre-term infants; they showed
significantly lower SOD and GPx activity and Se level, compared to the full-term infants (p<0,001,
for all). In the hyperbilirubinemic group, GPx activity and Se levels were found to be significantly
lower than those in healthy pre-terms (p<0.001, for both), while SOD showed highly increased enzyme
activity (p<0.001). Alterations
in enzyme activities were accompanied by a simultaneous significant
increase in the bilirubin level (p<0.001).
In conclusion, disequilibrium between SOD and GPx activity ratio may represent a marker of oxidative
stress in cells of premature infants. Aditionally,
this inadequacy of the protection, may cause
erythrocyte
haemolysis, resulting with hyperbilirubinaemia.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elizabeta Zisovska |
| Date Deposited: | 11 Aug 2015 09:15 |
| Last Modified: | 12 Sep 2016 10:27 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/13640 |
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