Application of high performance thin layer chromatography with densitometry for determination of active ingredients and preservatives in various pharmaceutical marketed formulations

Kostik, Vesna and Gjorgjeska, Biljana and Petkovska, Sofija (2015) Application of high performance thin layer chromatography with densitometry for determination of active ingredients and preservatives in various pharmaceutical marketed formulations. IOSR Journal of Pharmacy, 5 (4). pp. 7-15. ISSN 2250 - 3013

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Abstract

High performance thin layer chromatography(HPTLC) is a fast separation technique which is advantageous in many means as it is simple to handle and requires a short analysis time to analyze the complex or the crude samples. A new, simple, precise and sensitive analytical method based on HPTLC technique has been developed and validated for the estimation of eighteen active ingredients and preservatives in various marketed pharmaceutical formulations. The proposed method was accurate and precise (mean recovery in the range from 83.3% to 98.8%, precision with RSD<3.95%; LOQ < 26.4 μg/mL). This method was applied for the quantification of active ingredients and preservatives in: ophthalmic solutions, nasal solution, otic solution, syrups, shampoos, suppositories, ointments, dietary supplements, tablets and capsules.
Keywords: active ingredients, high performance thin layer chromatography (HPTLC), preservatives

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Vesna Kostik
Date Deposited: 16 Apr 2015 14:18
Last Modified: 16 Apr 2015 14:18
URI: https://eprints.ugd.edu.mk/id/eprint/13055

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