Smilkov, Katarina and Gjorgieva Ackova, Darinka and Gjorgoski, Icko and Janevik-Ivanovska, Emilija (2014) Rituximab-immunoconjugate kit-formulations for NHL radioimmunotherapy. Physioacta, 8 (2). pp. 113-120. ISSN 1857-5587
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Abstract
Radioimmunotherapy (RIT) of Non-Hodgkin’s lymphoma (NHL) is said to be more advantageous compared to unlabeled therapeutic antibodies. To this date, radiolabelled murine anti-CD20 mAbs, Zevalin® and Bexxar® have been approved for imaging and therapy. A preparation containing rituximab, chimeric mAb immunoconjugate suitable for Lu-177 labeling, could provide better imaging and therapeutic profile at the same time. This study was conducted to evaluate prepared lyophilized formulations of three rituximab immunoconjugates, intended for immediate Lu-177 labeling, for imaging and therapy.
The results showed preserved antibody structure and suitability for successful radiolabeling with over 95% radiochemical purity, encouraging further evaluation experiments.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Darinka Gorgieva Ackova |
| Date Deposited: | 10 Mar 2015 11:17 |
| Last Modified: | 13 Mar 2015 12:49 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/12886 |
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