Piperine as a natural derived NRF2 stimulator in prevention or therapy of ROS induced diseases

Maksimova, Viktorija (2023) Piperine as a natural derived NRF2 stimulator in prevention or therapy of ROS induced diseases. In: BenBedPhar Training School 2023 NRF2 in noncommunicable diseases: from bench to bedside, 26-30 June 2023, Smolenice, Bratislava, Slovakia.

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Abstract

Background: Piperine is the major alkaloid represented in Piper nigrum (black pepper) showing different pharmacological properties that are still extensively studied. Piperine’s ability to activate the protein expression levels of NRF-2 and HO-1 and inhibit the protein expression levels of Keap-1, is directly influencing the antioxidative capacity of the cells and ROS homeostasis.
Results: Activation of NRF2 by piperine has triggered an antioxidant response cell system (HO-1, GSH, CAT, SOD) scavenging ROS, and decreasing lipid peroxidation in colon cancer cells. These results indicate that piperine may be an effective molecule in the prophylactic aims of colon carcinogenesis by targeting the NF-κB/NRF-2/Keap-1/HO-1 pathway. The novel effects of piperine in attenuating oxidative stress in lung epithelial cells were shown recently. Treatment with piperine enhanced the NRF2 expression and reversed changes induced by cigarette smoke extract. Increased NRF2 levels promoted an anti-inflammatory effect in the same cells. Piperine has shown protective effects against Aβ-induced neuronal damage and oxidative stress, in the SH-SY5Y cell model. Activation of NRF2 pathway can also lead to inhibition of LPS-induced inflammatory response in microglial cells. In addition, a novel piperine derivative, HJ105, obtained through structure-based design and optimization was revealed in 2021, as a potent small molecule for the treatment of Alzheimer's disease. This structure promoted effective suppression of Keap1-NRF2 complex formation, and additional neuroprotective mechanisms of HJ105 underlying apoptotic cell death, oxidative stress response and neuro-inflammation.
Conclusion: Piperine and even more its derivatives are attracting increasing attention for their anti-apoptotic, anti-inflammatory, anti-antioxidant, cytoprotective and cognitive-enhancing effects.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Viktorija Maksimova
Date Deposited:	25 Dec 2023 08:56
Last Modified:	25 Dec 2023 08:56
URI:	https://eprints.ugd.edu.mk/id/eprint/33093

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