Bioactive compounds profiling in cultivated medical Cannabis

Serafimovska, Tijana and Tonic Ribarska, Jamina and Naumovska, Zorica and Darkovska-Serafimovska, Marija and Keskoski, Zlatko and Stefkov, Gjoshe (2023) Bioactive compounds profiling in cultivated medical Cannabis. In: 5th International Conference on natural products utilization: From Plants to Pharmacy Shelf, 30 May - 02 June, 2023, Varna, Bulgaria. (Unpublished)

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Abstract

Cannabis sativa is plant used to treat various painful and pathogenic conditions. The main carriers of pharmacological effects in cannabis flowers are cannabinoids and terpenes. Cannabinoids have been used in the treatment of chronic pain, spasticity, seizure disorders, nausea, anorexia. Terpenes itself have a wide range of pharmacological actions, such as antifungal, antiviral, anti-inflammatory, antimicrobial, and act synergistically with cannabinoids in exhibiting a pharmacological effect. The aim of this study was to determine cannabinoids content and terpenoid profile in dry cannabis flowers obtained from different THC-rich varieties of cannabis plant. For that purpose, a verification of HPLC/UV method for quantification of cannabinoids and GC/MS method for determination of terpenes in cannabis flowers was done to demonstrate that the analytical methods are suitable for intended analysis. Content of THC in Strawberry glue variety Lot.080322, Lot.110322 and Lot.040222 is 21.46%, 20.99% and 21.96%, respectively. Most common terpenes are beta-Myrcene, d-Limonene, beta-Caryophyllene and alpha-Terpineol. Content of THC in French Cookies variety Lot.060222, Lot.120322 and Lot.140422 is 22.17%, 23.05% and 22.55%, respectively. Most dominant terpenes are beta-Myrcene, d-Limonene, beta-Caryophyllene and alpha-Humulene. Content of THC in La Sage variety Lot.070222, Lot.090322 and Lot.110322 is 21.34%, 23.36% and 21.99%, respectively. Its unique aroma is a mixture of the dominant Terpinolene and beta-Caryophyllene and less represented, D-Limonene and beta Myrcene. The results obtained indicate that dry flowers derived from different cannabis varieties can be distinguished only by a terpenoid profile which is at the same time a fingerprint or a specificity that is characteristic of each variety.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Marija Darkovska-Serafimovska
Date Deposited:	16 Jun 2023 12:39
Last Modified:	16 Jun 2023 12:39
URI:	https://eprints.ugd.edu.mk/id/eprint/31905

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